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Cyanocobalamin (Vit B12)
Nme:Cyanocobalamin (Vit B12)
CAS:68-19-9
MF:C63H88CoN14O14P
The detailed specifications are as below:

Item of testing  Specification Result 
Appearance Dark-red crystalline powder or crystals conforms
Ratio of optical density A361/A550nm 3.15 ~ 3.40 3.28
A361/A278nm 1.70 ~ 1.88 1.86
TLC conforms conforms
Chemical positive positive
HPLC The retention time of major peak of the sample solution corresponds to that of the standard solution Correspond
Related substances  
Total impurities,% ≦3.0% 1.6%
Single impurities  
7β,8β-lactocyanocobalamin,% ≦1.0% 0.3%
50-carboxycyanocobalamin,% ≦0.5% Not detected
34-methylcyanocobalamin,% ≦2.0% 0.5%
32-carboxycyanocobalamin ≦1.0% Not detected
8-Epi-cyanocobalamin ≦1.0% Not detected

Item of testing  Specification Result 
Any other unidentified impurity,% ≦0.5% 0.3%
Loss on drying,% ≦12.0% 2.2%
Assay on dried basis,% 96.0~102.0% 99.0%
Residual solvents  
Acetone,ppm ≦1000ppm 16ppm
Ethanol,ppm ≦1000ppm 2.1×102ppm
Conclusion This product complied with the specifications of USP36 and Ph.Eur.7.0