Croscarmellose Sodium CAS 74811-65-7
Croscarmellose Sodium CAS 74811-65-7
This product is a cross-linked, partially carboxymethylated cellulose sodium salt. It occurs as a white or almost white powder. It swells in water, forming a suspension, and is insoluble in dehydrated ethanol, ether, acetone, or toluene. It is highly hygroscopic.
Product Details
| Test | Standard USP43 |
| Characters | White or greyish-white powder, hygroscopic |
| pH | 5.0-7.0 |
| Assay | Degree of substitution:It is not less than 0.60 and not more than 0.85, calculated on the dried basis |
| Loss on Drying | Maximum 10.0% |
Uses: Croscarmellose Sodium is used as a disintegrant in oral dosage forms, including capsules, tablets, and granules. In tablet formulations, it is suitable for both direct compression and wet granulation processes. During wet granulation, Croscarmellose Sodium is added using both intra- and extragranular addition to maximize the capillary and swelling actions of the disintegrant. When employed as a disintegrant, concentrations of up to 5% may be used; however, typical concentrations are 2% for direct compression and 3% for wet granulation.
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